The town of Caramanico, probably of Longobard origin, located at 700 meters elevation, is protected and ennobled by the Macella and Morrone Mountains.At the beginning of the 20th century the area grew considerably and this coincided with the construction of the thermal spas whose waters were an important centre for silk production noted in the 15th century.The sulphurous waters have the highest concentration of hydrogen sulphate in Europe, excellent for the treatment of respiratory problems. The application and maturation of the muds has been well developed.